![]() ![]() One cost-benefit analysis ( Moodie 2014) on people with cystic fibrosis in Australia and New Zealand found that the additional cost of BAL therapy compared to standard therapy was not offset by reductions in other healthcare expenditure over 5 years. Neither of these studies absolutely adhered to the clinical scenarios of the protocols. One single literature search was run for the 3 protocols, and 2 studies were included. We aimed to include systematic reviews, test and treat RCTs and prospective and retrospective observational studies.įor full details see review protocols in Appendix D. The committee were specifically interested in the value of adding invasive microbiological investigations and/or imaging techniques to non-invasive microbiological testing and lung function tests to evaluate treatment response in those with an acute pulmonary exacerbation. Of particular interest was the effectiveness of imaging techniques in addition to non-invasive microbiological techniques and spirometry. ![]() The committee were interested in comparisons of individual techniques within categories, individual techniques across categories and in combinations of techniques within or across categories. The committee recognised that those with no pulmonary disease would principally, but not exclusively be young children and that this review would inform investigative strategies to identify the onset of pulmonary disease, as opposed to identifying evolving pulmonary disease in the second population. Protocol 3: following an acute pulmonary exacerbation ![]()
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